- Weapon X is from the Christopher Yost Animated Universe.
- Professor Thorton: A powerless human who runs the program.
- Malcolm Colcord: A member of the Weapon X program.
- Sabretooth: A mutant who has been on Team X for years.
- X-23: A female clone of Wolverine who went through the adamantium bonding process.
- Deadpool: A member of Team X. Lived through the attack with the Hulk but was not seen with the team again.
- Lady Deathstrike: A member of Team X after Wolverine left. Apparently died during the battle with Hulk.
- Omega Red: A member of Team X. Apparently died during the battle with Hulk.
- Maverick: Brainwashed into joining. Rescued by Wolverine and his daughter Christie Nord.
- Mystique: Forced into joining but rescued by her lover Wolverine.
- Wolverine: Forced into the program then kidnapped and brainwashed into joining Team X. Escaped then recaptured along with Hulk. Fought the group again after he reformed the X-Men.
The history of the Weapon X program is unknown.
It is known that they kidnap and brainwash mutants for the programs. It is not known whether the team has or accepts volunteers. Some members seem more willing to be on the team than others, though this could be because of brainwashing.
They had Sabretooth, Wolverine, and Mystique in their program. But when they tried to experiment on Mystique, Wolverine helped her escape. They then captured him and bonded adamantium to his bones.
Wolverine joined Team X along with Deadpool, Omega Red, and Sabretooth. He eventually broke free of their control and escaped, slicing off the Professor's arm in the process.
They cloned Wolverine and put the twenty-third clone through the same bonding process.
Lady Deathstrike joined the team and they tried to capture Hulk for their experiments.
They tracked him down where he was battling Wolverine. Team X captured both of them.
Wolverine escaped and released the Hulk. Hulk defeated the team and blew up their Canadian facility.
Deathstrike and Omega Red were apparently killed. Deadpool survived but apparently did not go back to the team.
Weapon X captured and brainwashed Maverick. Mystique found out and got Wolverine to help her rescue him.
Wolverine then encountered X-23, his clone.
Omega Red, Lady Deathstrike, and Mystique are not normally associated with Weapon X. Though, X-Men did state that Lady Deathstrike's father was the Professor whose death is the reason for her hatred towards Wolverine.