Following the Season two cliffhanger, Spider-Man must work with Doctor Strange to free Mary Jane Watson from the clutches of Baron Mordo and Dormammu. He would face familiar enemies in Doctor Octopus, Tombstone, and Hobgoblin. The wallcrawler's greatest threat would come from an entirely new batch of villains. Peter would have to decide what to do when his student steals technology from Big Wheel to become the Rocket Racer. Venom returns alongside his "son" Carnage. The Spot would create a device that causes massive chaos. He would have help from Daredevil and Iron Man and receive enigmatic advice from the mysterious Madame Web, who seems to be training him for some great battle. But the worst would come when his best friend's father becomes the dreaded Green Goblin.