|Real Name||Spencer Smythe|
|Powers and Abilities||Expert in Robotics|
|Team Affiliations||OsCorp Industries|
|Allies|| Norman Osborn|
|Family and Friends||Alistair Smythe (Son)|
Spencer was the man who originally designed the Spider Slayers. He designed them for Norman Osborne who was working for The Kingpin. Hoping that once Spider-Man has been captured, Norman would create a new chair in which his paralyzed son, Alistair would be more comfortable with.
After the slayer caught the wrong person, Spider-Man and the first Spider Slayer, the Black Widow fought in OsCorp Industries, which exploded, leading everyone to believe, Spencer, who was trapped inside, had died.
However, Spencer somehow survived the explosion. Kingpin found him in the ruins of OsCorp and then placed him in cryogenic suspension. The Kingpin then met with Alistair and told him that Spider-Man was responsible for his father's demise in order to convince him to work for him. Once Alistair discovered the truth, he began devoting his full attention into reviving his father and vowed to take revenge on the Kingpin. It is unknown if he ever managed to revive Spencer.
Spencer was voiced by Edward Mulhare.
This is the second animated version of the character, following his appearance on Spider-Man where the character was named Henry Smythe. This is the first to use his real name.
This is currently the last version of the character.
He only had one episode of being active. Every other appearance was either a flashback or in cryogenic stasis.
Interestingly, the one slayer he is shown building in the series was not built by him in the comics but by Alistair.
In the Comics
Spencer was hired by J. Jonah Jameson and built several Spider-Slayers.