|Alternate Identity||Curtis Connors|
|Powers and Abilities||Healing Factor, Incredible Strength, Speed, and Durability; Wall-Crawling|
|Family and Friends||Martha Connors (Wife)|
Billy Connors (Son)
Curtis Connors lost his arm while working as a surgeon in the United States Army. He became so desperate on regrowing his arm, that he tested his reptile potion on himself. He later found work as a biologist at Empire State University, studying reptiles and cell regeneration.
Connors' experiments with lizard DNA proved more than he could handle. The serum regrew his arm but also turned him into a giant green lizard-like creature. Spider-Man, Eddie Brock, Gwen Stacy, and Connors' wife Martha Connors developed a formula that would turn him back. It worked, though Spider-Man took a picture of himself fighting Lizard. They decided to keep his transformation a secret.
Peter Parker then sold that picture to The Daily Bugle. However, Martha felt she could not trust that Peter wouldn't reveal the secret if he would sell photos and ended his internship.
Connors transformed again, but was stopped by another antidote.