User blog comment:ARTaylor/Ultimate Spider-Villains/@comment-4499844-20120315225104/@comment-122823-20120318031329

It'll probably be based off both the Ultimate and 616 versions. So far, no series or film (animated or live-action) has been completely taken from the Ultimate. Even the Ultimate Avengers films had elements from 616. The New Animated Series and Spectacular Spider-Man were combinations of the two so this series will likely follow suit, despite the name.