High Evolutionary

X-Men
In the  X-Men  episode "Savage Land, Savage Heart" Pt. 2, the High Evolutionary appeared in a flashback  fighting  Garokk  and traps his essence in the ground of the  Savage Land. In "Family Ties," the High Evolutionary (voiced by Bruce Tubbe ) is shown to be the Master of  Wundagore. When Quicksilver  and  Scarlet Witch  came to Wundagore to find Lady Bova, he was unsure it was them at first until he used his machine to find out it was them. After Lady Bova reveals the truth about their father being Magneto, the High Evolutionary told them that he was at a nearby cemetery and sends some of his warriors to accompany them. When Magneto is taken down, the High Evolutionary's New Men restrain Quicksilver and Scarlet Witch. When Wolverine attacked, knock-out gas filled the area causing him, Magneto, Quicksilver, and Scarlet Witch to become prisoners of the High Evolutionary. He seeks to create a superior generation of his New Men by using mutant   DNA, mutating humans into beast-like beings, instead of experimenting on animals. He sets up a trap to capture Magneto. After he reveals that fact and mentions to Quicksilver and Scarlet Witch that Magneto is their father, he takes Wolverine and uses his genetic machine to turn him into a werewolf-like monster. When Professor X and Beast arrived in Wundagore, the High Evolutionary instructed his New Men to bring him Beast. After a brief fight with the X-Men, the High Evolutionary escapes with his New Men. The effects he caused on the valley his fortress was in were reversed as was Wolverine's transformation.

Spiderman Unlimited
The High Evolutionary appears as a principal villain in Spider-Man Unlimited voiced by Richard Newman. He had created Beastials (half-humans, half-animals) on a planet called Counter-Earth with The Knights of Wundagore (who were Sir Ram, Lord Tiger, Lady Ursula, and Lady Vermin). In the second to last episode of the series, it was revealed to the High Evolutionary that he is the grandfather of Karen O'Malley and that he experimented on her when she was young. The High Evolutionary was defeated during the series finale in a fight against Spider-Man and The Rebellion.